The first hole in a given pair of my pants is almost always in the knee.

I'm not trying to be funny, but mine always seem to get a hole in the crotch.

I should have excluded holes that are intentionally added with scissors...

Either the section where four pieces of fabric connect, in the crotch, or around the bottom right hem, by the ankle.

Crotch

My wallet always rips holes in my back pocket

right inner ankle, from my the chainring on my bike.

BE: The right cuff on my pants often gets a little worn but I wasn't counting that as a hole, per se.

Cuffs. They don't just get worn, they get pretty banged up.

That, and I occasionally end up with weird, inexplicable holes mid-leg; I think there've been moth attacks on my pants.

The pants that I'm wearing now also have a mystery hole on the side of the knee. There's no wear, though. I must have snagged them on something.

Ooh. I hate it when that happens.

Cuffs here as well..

In the crotch